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KMID : 0378019680110070047
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New Medical Journal
1968 Volume.11 No. 7 p.47 ~ p.53
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On the Degranulation of Mesenteric Mast Cells Caused by Antihistamine in Albino Rats
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姜浩錫/Kang, Ho Suck
文炳烈/方爀/朴滿洙/朴秀淵/Moon, Byong Yull/Bang, Hyuck/Park, Man Soo/Pak, Soo Yun
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Abstract
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The tissue mast cells, which contain metachromatic or orthochromatic granules in the cytoplasm, have baen described in the literature as a source of heparin, histamine, hyaluronic acid, serotonin and certain mucopolysaccharides. The metachromatic granules of the mast cells in the connective tissue were readily diffused or degranulated from the cells by certain chemical administration.
It is well known that the histamine was liberated by the administration of histamine liberators, such-as compound 48/80 and others associated with degranulation of the mast cells.
Additionally it was reported that the concentration of histamine in blood was increased after the administration of various antihistamines. However, the accompanying histological feature of mast cells due to administration of various antihistamines was controversial according to the authors.
The present experiment was undertaken to find out whether antihistamine releases the metachromatic granules from the mesenteric mast cells in albino rats after administration of the antihistamine.
Chlorpheniramine(0.6 mg. /kg.) in normal saline solution and Tyrode solution was intravenously and intraperitoneally given in a single dose. The mesenteric mast cells were stained in Pugh´s solution containing toludine blue which was applied by Lee (1968).
The results were as follows:
1. In the experimental group of chlorpheniramine giN en intravenously, slight or moderate degranulation of the mast cells shoved with the incidence of the normal mast cells occurring about (90.21-5%) compared with an incidence of 98.20.2% in the control group.
2. In the experimental group of chlorpheniramine given intraperitoneally, slight degranulation of the mast cells occurred with the incidence of the normal mast cells counting about 92.74-1.2% compared with an incidence of 95.7.12.0 % in the control group.
Consequently~it is deduced that the experimental dosage of . antihistamine, chlorpheniramine maleate applied by Lee et al. (1960) caused an evident degranulation of the mesenteric mast ceIIs of the albino rats associated with the probable histamine liberation.
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